One of the game's great rivalries will mark the official opening of the new Allianz Stadium, with the winner set to secure a home match for the opening week of the finals.
Since their bye in round 17 the Roosters haven't lost a game and last week knocked off another of the NRL's form sides, the Storm, in a gritty contest at AAMI Park.
The Rabbitohs too had a statement win last up, overcoming the late loss of star hooker Damien Cook to a positive COVID-19 test to beat the Cowboys.
Earlier this year South Sydney were 28-16 winners over their old foes at Accor Stadium.
Sportsbet Betting preview: Roosters v Rabbitohs
The Rundown
Team news
Roosters: Boom youngster Joseph Suaalii has been withdrawn on Thursday after sustaining a shoulder injury last week. His place is taken by Kevin Naiqama. The loss of Victor Radley (concussion), Daniel Tupou (groin) and Lindsay Collins (suspension) sees Siosiua Taukeiaho and Paul Momirovski join the starting side with Terrell May and Oliver Gildart the new faces on the bench, with the Englishman replacing Fletcher Baker when the teams were finalised 60 minutes before kick-off.
Rabbitohs: Damien Cook has been sidelined by COVID so Siliva Havili again fills the hooking role. Centre Campbell Graham is out injured, replaced in the starting side by Jaxson Paulo. Utility Kodi Nikorima was initially named as 18th Man with Peter Mamouzelos taking his place on the bench but he received a late call-up in place of Michael Chee Kam when the squads were finalised 60 minutes before kick-off. Coach Jason Demetriou also tested positive to COVID during the week so he will miss the blockbuster clash.
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Key match-up
James Tedesco v Latrell Mitchell: The clash between these two superstar fullbacks is almost worth the price of admission on its own. The one-time Tricolours teammates are the key attacking weapons for their respective sides, with Mitchell averaging the most try assists per game (1.2) in the whole competition and Tedesco the NRL's top tackle breaker, averaging 7.3 per game.
Stat Attack
Alex Johnston has enjoyed the most prolific try-scoring regular season of his career in 2022, with his 28 four-pointers taking him past his previous best normal season mark of 27, achieved last year. With the finals approaching, the 27-year-old needs just two tries to equal his best season tally (including finals) of 30, again achieved in 2021. In addition to leading the try-scoring tally, Johnston's 37 line breaks are also the most in the NRL, putting him 10 clear of second-ranked Ronaldo Mulitalo.
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