The Panthers may be sitting pretty on top of the ladder with just one loss in 11 rounds, but a group of NRL.com tipsters are sensing another Manly ambush.
Just as the Sea Eagles did against then-ladder toppers Parramatta two weeks ago, there is a view Des Hasler's men can repeat that feat when Ivan Cleary's men visit Lottoland on Saturday.
Apart from the Panthers-Manly showdown, the clash between the Sharks and Broncos is the other Round 12 meeting to have divided opinion.
It's time to get your tips in - enter them now to make sure you don't miss out.
If you need help on how each team is travelling, Jamie Soward's Power Rankings is the best place to go for an accurate gauge on who's travelling well and who's doing not so well.
Here are the NRL.com expert panel's predictions for the round.
On the NRL.com tipping leaderboard, Ladies Who League founder Mary Konstantaopoulos maintains a one-point lead over Fantasy NRL mystery man Lone Scout. There are just four points separating the top six on the leaderboard.