Tyson Frizell will make a remarkable return for the Dragons just three weeks after undergoing surgery on a lacerated testicle against the Knights on Sunday evening.
Frizell emerged unscathed from St George Illawarra's captain's run on Saturday and will come from the extended reserves list into Paul McGregor's game day 17.
The NSW Origin and Kangaroos back-rower is expected to come onto the bench in place of youngster Luciano Leilua given Jacob Host has performed well in the starting line-up.
Frizell had been initially slated for a 4-6 week layoff when he reeled out of a tackle on North Queensland's Jordan Kahu in round one. Surgery was required.
Knights v Dragons - Round 4
His return is a significant boost for the Dragons given they are still without NSW team-mate Jack de Belin, stood down by the NRL until his next court appearance on sexual assault charges on April 17.
Korbin Sims and Blake Lawrie are tipped to rotate in the middle, allowing Frizell to switch back to his usual right edge having covered de Belin at lock in the season opener.