Dragons fullback Josh Dugan has been ruled out of his side's Round 20 meeting with the Sea Eagles due to a hamstring complaint.
"Josh Dugan presented with hamstring soreness post the Round 19 game against the Raiders," Dragons head of athletic performance Nathan Pickworth told dragons.com.au.
"Upon follow-up scans it was determined that he would miss this weekend's game against Manly.
"He will be reviewed and progressed accordingly over the next couple of days."
Dugan, who failed to finish his side's golden point loss to the Raiders after receiving a high shot from Josh Papalii, will be replaced by Jason Nightingale at the back. Kurt Mann has been promoted to the starting side on the wing, with Matt Dufty coming on to the bench.
Russell Packer could still force his way into the gameday side, listed in the reserves when the squad was cut to 19, with Jake Marketo dropping out of the squad.
The Sea Eagles have also been dealt a blow with Brenton Lawrence out of the Manly side, Lloyd Perrett to start in the front row. Jarrad Kennedy is the man most likely to come on to the final interchange, with Joey Lussick and Jonathan Wright still among the reserves.
Lewis Brown is the other player to drop out.
Updated Dragons squad
5 Jason Nightingale
2 Nene Macdonald
3 Euan Aitken
4 Timoteo Lafai
17 Kurt Mann
6 Gareth Widdop (c)
7 Josh McCrone
8 Leeson Ah Mau
9 Cameron McInnes
10 Paul Vaughan
11 Tyson Frizell
12 Joel Thompson
13 Jack de Belin
Interchange
14 Tariq Sims
15 Jacob Host
16 Blake Lawrie
18 Matthew Dufty
Reserves
19 Taane Milne
20 Russell Packer
Updated Sea Eagles squad
1 Tom Trbojevic
2 Brad Parker
3 Dylan Walker
4 Brian Kelly
5 Akuila Uate
6 Blake Green
7 Daly Cherry-Evans (c)
15 Lloyd Perrett
9 Cameron Cullen
10 Martin Taupau
11 Frank Winterstein
12 Shaun Lane
13 Jake Trbojevic
Interchange
14 Jackson Hastings
16 Darcy Lussick
17 Addin Fonua-Blake
18 Jarrad Kennedy
Reserves
19 Joey Lussick
21 Jonathan Wright