Issac Luke and Solomone Kata will return for the Warriors this week, with Charnze Nicoll-Klokstad and injured duo Albert Vete and Nathaniel Roache making way.
Luke will start at hooker with Roache out with a hamstring injury, while Albert Vete's broken arm means Sam Lisone gets a spot on the bench.
Solomone Kata returns at centre with David Fusitua moving to the wing and Nicoll-Klokstad dropping to the extended bench.
The Warriors will farewell club legend Manu Vatuvei in Friday night's clash with the Panthers ahead of Vatuvei's exit to the Super League to link up with Salford. Mount Smart Stadium will be temporarily renamed Manu Vatuvei Stadium for the night in honour of the departing winger.
Warriors side to face Penrith
1 Roger Tuivasa-Sheck (c)
2 David Fusitua
3 Blake Ayshford
4 Solomone Kata
21 Ken Maumalo
6 Kieran Foran
7 Shaun Johnson
8 Jacob Lillyman
9 Issac Luke
10 Ben Matulino
11 Bodene Thompson
12 Bunty Afoa
13 Simon Mannering
Interchange:
14 Ata Hingano
15 Samuel Lisone
16 James Gavet
17 Liligiifo Sao
18 Charnze Nicoll-Klokstad
20 Tevita Satae
22 Jazz Tevaga
24 Mason Lino